In this interview, Jon Phillips, oral historian at AIP, interviews David Rose, Professor Emeritus of Biology at the University of Waterloo. In this interview, Dr. Rose discusses his education in physics and biology as an undergrad at Penn. He then discusses his graduate studies under David Phillips at Oxford University, and his introduction to crystallography while there. He describes his post-doctoral work with Gregory Petsko at MIT, and the growth of crystallography in the US at that time. He recounts his transition to the Canadian National Research Council in Ottowa, where he worked on protein crystallography and glycobiology. He goes on to discuss his move to the University of Torontos Princess Margaret Hospital, where he spent the majority of his career. Finally, Rose discusses his time at the University of Waterloo, teaching and research during the COVID-19 pandemic, and his tenure as President of the American Crystallographic Association.