In this interview, David Nygren discusses: the problem of the university and specialization in addressing global challenges; reaction to the muon anomaly in the g-2 experiment at Fermilab; work on particle physics with at University of Washington; experimentation at Berkeley lab; post-doc at Columbia with Jack Steinberger working to measure the semileptonic charge asymmetry in neutral kaon decays to find evidence of CP symmetry violation; building an MWPC-based detector; experimental work with Owen Chamberlain and the Bevatron, developing the Bevalac; invention and design of the Time Projection Chamber (TPC) at Berkeley; early models of the TPC and concerns during development; Pief Panofsky; PEP-4 TPC success; involvement with doomed supercolliding super conductor (SSC) project; development of pixel-based vertex detector/smart pixel arrays; making deep-depletion charge coupled devices (CCDs) with Steve Holland; Carl Rubbia; x-ray mammography research with leading to the Philips MicroDose System; contributions to the NESTOR Project neutrino muon detector; involvement with IceCube and gathering digital data; discussion of the AMANDA array; using gas time projection chamber to look for neutrinoless double beta decacy (NLDBD); collaboration with Juan Jos ̌Gm̤ez Cardenas; using biochemistry to make connections for NLDBD discoveries; the question of whether the neutrino is its own antiparticle; development of Single Molecue Fluorescence Imaging (SMFI); Q-Pix idea; progress building Q-Pix detectors; work at UTA using the Earth-Human System as a way to reorient the university toward the big picture of climate change. Toward the end of the interview, Nygren reflects on his own eureka moments, the failures that led to deeper learning, his mixed feelings about the future of the planet, and the belief that physics can be a training ground for the new ideas humanity will need.