In this interview, Fabiola Gianotti, Director-General of CERN, reflects on being the first woman in this position and the multi-layered challenges of maintaining operations at CERN during the pandemic. She recounts her upbringing in Milan and the scientific influence of her father, who was a geologist. Gianotti describes her education at the University of Milan and her formative interactions with Carlo Rubbia at CERN. She describes her work on the LEP and ADELPH collaborations and how the cancellation of the SSC affected CERN. Gianotti narrates the origins of the LHC and parallel concentration on supersymmetry and she describes the ATLAS and CMS teams and her advisory work for P5 in the United States. She discusses her election and responsibilities as Spokesperson of ATLAS and she describes the careful process of detecting and analyzing the signals that confirmed the Higgs. Gianotti describes the unique opportunity to engage a global audience given the magnitude and interest in the discovery, and she explains LHCs planning, post-Higgs, for new physics. She describes the shutdown period that started in 2013 and the circumstances to her being named Director-General in 2013. Gianotti surveys what has, and has not, been detected at the LHC over the past decade, and how dark matter searches at CERN are complementary to those using Xenon detectors. She conveys optimism about the high luminosity upgrade at the LHC and how she frequently operates in political realms given the international nature of CERN. At the end of the interview, Gianotti observes that current projects at the CERN are reminiscent of the buildup to the LHC, and why this bodes well for the future of experimental particle physics.