Interview with William H. Press, Leslie Suringer Professor in Computer Science and Integrative Biology at the University of Texas at Austin. Press recounts his childhood in Pasadena and the influence of his father Frank Press, who was a prominent geophysicist, Caltech professor, and who would become science advisor to President Jimmy Carter. He describes the impact of Sputnik on his budding interests in science, and he discusses his undergraduate experience at Harvard, where Dan Kleppner, Norman Ramsey, Ed Purcell and Dick McCray were influential in his development, and where he realized he had an aptitude for applying abstract equations to understanding physical reality. Press describes trying his hand with experimentation in Gerald Holtons high-pressure physics lab, he recounts his involvement in student activism in the late 1960s, and he discusses his involvement in computer hacking in its earliest form. He explains his decision to attend Caltech for graduate school and his interest in studying with Dick Feynman and Kip Thorne. Press describes the opportunity leading to his work at Lawrence Livermore, how he got involved with Thornes group of mathematical general relativists, the origins of Thornes work on gravitational waves, and his collaborations with Saul Teukolsky and Paul Schechter. He describes the formative influence of Chandrasekhar. Press discusses his first faculty position at Princeton where he joined John Wheelers relativity group, and he describes his research interests flowing more toward astrophysics. He explains the opportunities leading to his tenure at Harvard, where he was given separate appointments in physics and astronomy and where he founded theoretical astrophysics within the Center for Astrophysics. Press describes his entrě into science policy work in Washington with the NSF Physics Advisory Committee and then later on the National Academy of Science and the National Research Council, and he explains the origins of his long-term association with the JASON Study Group. He describes his interest in gravitational collapse, supernovae and galaxy formation, and why the study of black holes reinvigorated the field of general relativity. Press describes the singular genius of Freeman Dyson, and he recounts his contributions to nuclear risk reduction in science policy and his service with the Defense Science Board and the Institute for Defense Analyses. He discusses his tenure as chair in Harvards Department of Astronomy, his experience with the "Numerical Recipes" books, and his collaboration with Adam Riess and Robert Kirshner. Press recounts his decision take a position at Los Alamos as Deputy Director to John Browne, he describes his education there in the concept of leadership which he never received in his academic career, and he provides his perspective on the Wen Ho Lee spy case and the existential crisis this caused at the Lab. He describes the Labs role in the early days of computational biology and how this field sparked his interest. Press contextualizes this interest within his conscious decision not to stay connected to astrophysics during his time at Los Alamos, and he explains the opportunity leading to him joining UT-Austin where he remains invested in computational biology. He describes his work for the Presidents Council of Advisors in Science and Technology during the Obama administration, he describes Obamas unique interest in science and science policy, and he narrates the difficulties in the transition to the Trump administration. Press reflects on what it means to be a member of the rarified group of scientists who did not win a Nobel Prize but who were advised by and taught scientists who did. At the end of the interview, Press explains that he has always been a dilettante, which has and will continue to inform how he devotes his time to science, service, and policy matter, and he advises young scientists to aspire to mastery in a specific discipline early in their career before branching out to new pursuits.