Interview with Lu Sham, Distinguished Professor of Physics Emeritus, University of California at San Diego. Sham recounts his childhood in Hong Kong and he describes the legacy of Japanese rule from World War II. He describes his early interests in math and he explains his decision to pursue a higher education in England at Imperial College. Sham discusses his motivation to conduct graduate work at Cambridge University and to study under Nevill Mott on the first principle method calculating the electron contribution to lattice vibration. He describes the help provided by John Ziman to secure his postdoctoral position at UC San Diego to work with Walter Kohn, and he describes the foundational collaboration and research that went into the Kohn-Sham equation and how this work builds on the classic debate between Einstein and Bohr. He describes the opportunities leading to his faculty appointment and eventual tenure on the physics faculty, and he explains the benefits of spending summers doing research at Bell Labs. Sham discusses his contributions to research on semiconductors, quantum computing, and density-functional theory. He describes his more recent interest in optics and the formative work he has done with graduate students and postdoctoral researchers over the years. Sham discusses his administrative service as department chair and Dean of Science. At the end of the interview, Sham asserts that the future of condensed matter physics holds limitless possibilities, and that improvements in semiconductor materials will push quantum information abilities in exciting and unforeseen directions.