Interview with Roger Blandford, the Luke Blossom Professor at the School of Humanities and Sciences at Stanford University and Professor of Physics at SLAC. He discusses his current work developing alternate understandings of the Event Horizon Telescope image, on fast radio bursts, and on the notion that handedness has astrophysical origins. Blandford describes the history of cosmology as a respectable discipline within physics, and he credits the rise of VLBI in the 1960s and 1970s for demonstrating the evidence of black holes. He recounts his childhood in England, his early interests in science, and his education at Cambridge, where his thesis research on accretion discs and radio sources was supervised by Martin Rees. Blandford discusses his postdoctoral work on astrophysical particle acceleration and plasma and QED processes in pulsars and a formative visit to the Institute for Advanced Study and to Berkeley. He describes his initial impressions of Caltech where he joined the faculty and where he worked closely with Roman Znajek, and he explains the distinctions between radio jets and relativistic jets. Blandford explains his reasons for moving to Stanford to set up the Kavli Institute and he describes his involvement with the Astronomy and Astrophysics Decadal Survey. At the end of the interview, Blandford contends that the most exciting developments in the field have been on exoplanet research, why the possibilities in astrobiology give him cause for optimism, and why the concept that astronomical discovery arrives as logically unscripted resonates with him.