In this interview George E. Smith, professor in the Department of Philosophy at Tufts University, discusses his life and career. He recounts his childhood in Cincinnati and his undergraduate research at Yale where he majored in the philosophy and mathematics program. He discusses his work at General Electric and Pratt & Whitney, and its influence on his subsequent academic interests. Smith describes the circumstances that led to his graduate study at Harvard and his formative relationship with Noam Chomsky. He explains his decision to move to MIT to work under Dick Cartwright on quantified modal logic, his consulting work in Boston, and the offer that brought him to join the faculty at Tufts. Smith discusses his tenure as head of the Dibner Institute and the impact of Thomas Kuhns scholarship on his research agenda, which led to his long-term interest in the philosophical implications of physics. He traces the historical interplay of theory and experimentation going back to Einstein and he defines the term microphysics. Smith explains why physicists such as Steve Weinberg see value in his work on the philosophy of evidence and he describes his longstanding research project on Newton and why the physics he discovered remains relevant. He discusses the scientific and philosophical challenges inherent in understanding climate change and the long-range dangers of nuclear waste. At the end of the interview, Smith reflects on his teaching achievements, and why philosophy of science was and will remain indispensable to a shift from thinking about science as something to be learned in a classroom toward using it to learn about the world.