In this interview, David Zierler, Oral Historian for AIP, interviews Mary Jo Nye, Professor of History Emerita, and former Horning Professor of Humanities at Oregon State University. Nye recounts her childhood in Nashville and she discusses her developing dual interests in science and history. She discusses her undergraduate work at Vanderbilt and then at the University of Wisconsin, where she decided to focus on history for graduate work. Nye describes her graduate work in the History of Science department at Wisconsin where she worked with Erwin Hiebert, and she explains the various challenges of navigating career opportunities as one-half of an academic couple. Nye describes her formative time doing postdoctoral research in France, and describes her career at the University of Oklahoma prior to joining the faculty at Oregon State. The bulk of the interview covers Nyes contributions to the history of physics, including her work on Big Science, theoretical chemistry, Polanyi, modernization, Pauling, among other diverse topics. Nye discusses her contributions to history of physics as a teacher and graduate student mentor, and she describes how the field has changed over the course of her career. At the end of the interview Nye discusses her current interest in the history quantum mechanics and quantum chemistry.