Records about Wiesner's activities at MIT include correspondence, memoranda, and reports from the Department of Electrical Engineering, correspondence about his involvement with the Council for the Arts, and information about his fund raising efforts. A tribute from the MIT faculty upon his retirement from the MIT presidency in 1980 is included. Wiesner's consulting to government, industry, private foundations, and other groups such as the President's Science Advisory Committee, 1960-1961, 1964-1972, the Public Broadcasting System, the Cambridge Radio Observatory Committee, the Sloan Commission on Cable Communications, the New England Solar Energy Center, and the Massachusetts Governor's Advisory Committee on Science and Technology is documented in correspondence and subject files. The collection documents his involvement with Pugwash and other political and professional societies, including the National Academy of Sciences and the National Academy of Engineering. Copies of speeches, radio and television interviews, copies of his publications, and correspondence reflect Wiesner's concern about arms control, the space program, energy, and underdeveloped countries. There are several audiocassettes of speeches and lectures he gave. Some personal correspondence and correspondence logs are included.

Wiesner's official MIT records form a separate collection in the Institute Archives: AC 8, Massachusetts Institute of Technology. Office of the President.

Wiesner's records as science advisor to President John F. Kennedy are located at the John F. Kennedy Library, Columbia Point, Boston, Mass.