In this interview, David Zierler, Oral Historian for AIP, interviews John Browne, former Director of Los Alamos Laboratory. Browne recounts his working-class childhood in Pennsylvania. He discusses his early interests in science and the influence of his father, who was an electrician. He explains his decision to attend Drexel, and the factors leading his commitment to major in physics. Browne describes his graduate studies at Duke University, where he worked on techniques to create a feedback system with an atomic beam and a molecular beam. He discusses his decision to join Lawrence Livermore National Laboratory and then Argonne National Laboratory. The bulk of the interview concerns Brownes tenure at Los Alamos where he worked on the weapons program and diagnostic testing. He discusses his promotions at Los Alamos and his increasing communication with the DOE on policy relevant issues. Browne discusses his decision to accept the directorship at Los Alamos and the numerous security and accounting issues he had to deal with, which included the major security breach involving Wen Ho Lee. He discusses the creation of the NNSA and the impact of September 11th on Los Alamos and the national security world generally, and in the last portion of the interview, Browne describes his ongoing work in consulting and professional service.