The collection documents the professional life and career of Victor Frederick Weisskopf (1908-2002) from the 1920s through 2002. Educated in Europe in the 1920s and 1930s, Weisskopf made important contributions to the quantum theory of radiative transitions, the self-energy of electrons, the electrodynamic properties of the vacuum, and the theory of nuclear reactions. In 1943, several years after his move to the United States, Weisskopf was invited to join the Manhattan Project, where he served as deputy chairman of the theoretical division. He was a member of the faculty at the Massachusetts Institute of Technology in the Department of Physics starting in 1945, Institute Professor from 1965, and Institute Professor Emeritus from 1974. In addition to his research and teaching activities, Weisskopf played a major role in shaping the development of high-energy particle physics in the US and in Europe, serving as director general of the European Organization for Nuclear Research (CERN) between 1961 and 1965 and chair of the High Energy Physics Advisory Panel (HEPAP) from 1967 through 1973. Throughout his life he was involved in activities of many professional organizations including the Federation of Atomic Scientists, Pugwash Conferences, American Physical Society, American Academy of Arts and Sciences, and the Pontifical Academy of Science. The bulk of the collection dates from the 1960s through the 1990s, reflecting Weisskopfs role as a physicist, educator, administrator, scientific statesman, and advocate of social and political causes.