This interview was conducted by Morgan Seag for her graduate research work on the U.S. Antarctic Program at the Scott Polar Research Institute, University of Cambridge. In this interview, Mosley-Thompson discusses her family background and upbringing in West Virginia, her interest in science from an early age, her decision to study physics in college, and the happenstance manner in which she became involved with the Institute of Polar Studies at the Ohio State University. Mosley-Thompson describes extracting the climate history of an Antarctic ice core for her Ph.D. and the circumstances leading to her first visit to Antarctica in 1982, and what it was like to be among the first female scientists working in this field. The interview covers Mosely-Thompsons subsequent trips to the Antarctic and other locales for field research, and her thoughts on the changing programmatic and research aspects of the field over the past three decades. Mosley-Thompson also discusses her involvement in federally supported research initiatives and her specialized contributions in data analysis and graphing, while balancing family and research responsibilities with her husband and fellow scientist and Ohio State University professor Lonnie Thompson. The interview concludes with Mosely-Thompsons description of her work as Director of the Byrd Center and her ongoing interest in research and teaching.