This interview covers three major subjects: Mildred Dresselhaus's scientific career, her role expanding opportunities for women in science, and her positions of leadership in the physics community. The portion on her scientific career includes Dresselhaus's graduate training at the University of Chicago developing a thesis on superconductivity, her transition to Lincoln Laboratories and transitioning into carbon research, teaching solid state physics at MIT after joining the Electrical Engineering department in 1967, the beginnings of nanotechnology, and her approach to research supervision. The portion covering Dresselhaus's efforts to promote opportunities for women in science focuses on MIT and in particular her efforts to build support networks for female students and faculty and to reform the Institute's admission standards. It continues with her reflections on the changes she's witnessed over the course of her career. The final section addressing Dresselhaus's leadership positions covers her efforts to expand international collaboration, intersociety relations in the physics community, and her observations about science and politics. Other topics include: J. Robert Schrieffer, James Franck, Arthur von Hippel, Dagmar von Hippel, Paul Richards, Brian Pippard, Francis Bitter, Abby Rockefeller Mauze, Andre Geim, Yuki Nakamitsu, Morinobu Endo, Patricia Dehmer, Nancy Hopkins, Jing Kong, Ken Cole, American Institute of Physics, American Physical Society, Bill Clinton, and the Superconducting Super Collider.