Susan Solomon describes the beginning of her early interest in science and family background. She discusses her undergraduate work and graduate work at University of California Berkeley in Chemistry. She then describes her meeting with Paul Crutzen and Jack Fishman. and University Corporation for Atmospheric Research (UCAR) graduate fellowship work with ozone sonde measurements. She then talks about her thesis work at National Center for Atmospheric Research (NCAR) and first position at the National Oceanic and Atmospheric Administration (NOAA) Aeronomy Lab in Boulder. She discusses the use of the Residual Eulerian framework for describing stratospheric transport, and the effect of publication of observations of ozone depletion by British scientists. She details theories about the cause of ozone depletion and her work on surface chemistry effects on ozone. She reflects on the idea of chemical intuition.Solomon describes the 1986 field trip to Antarctica, including her being chosen as group leader, the first measurements of chlorine dioxide, and her contribution regarding making diurnal and nocturnal measurements. She discusses the subsequent data analysis and related political and social issues. She reflects on her election to the National Academy of Sciences and the French Academy, and comments on the contribution of Nobel Prize winners Paul Crutzen, Sherwood Rowland, and Mario Molina. Finally, Solomon describes the role of mentoring in science, and notes the mission of atmospheric chemistry and its relation to public service.