Interview covers Charles Misner's family background and childhood interest in science; influential chemistry teacher in high school; education at Notre Dame and mentorship with Arnold Ross; early interest in mathematics; encouragement of parents to go into science or to become a priest; graduate education at Princeton; work with John Wheeler on relativity and topology; introduction to cosmology by Jim Peebles in 1965; attitude toward the steady state model; Wheeler's preference for a closed universe; history of the flatness problem (the "Dicke paradox"); initial attitude toward the flatness problem; motivation for looking for mechanisms to isotropize the universe; the mixmaster model; history of the horizon problem; Misner's attempt to change the goals of cosmology from describing the universe to explaining it; Russian work on mixmaster type models; reaction of the community to the mixmaster model; change in Misner's view of the flatness problem after the inflationary universe model; attitude toward missing matter; problem of reconciling theory and observations with a flat universe; Misner's attitude toward the inflationary universe model; attitude of the community toward the inflationary universe model; attitude toward recent observations of large-scale structure; nature of the inhomogeneity of the universe; importance of Freeman Dyson's discussion of the fate of an open universe over very long time scales; role of visual pictures in science; relationship of theory and observation in cosmology; outstanding problems in cosmology; inflation, particle physics, quantum cosmology; ideal design of the universe; philosophy, science, and religion; necessity of the laws of physics; question of whether the universe has a point.