The program honored the vision of John Archibald Wheeler in his 90th birthday year. The challenge was to take this vision forward into a new century of discovery. Wheeler is renowned as both a research leader and as an extraordinary teacher for many of the 20th century's most creative physicists. The symposium brought together over 300 accomplished leaders and visionary younger scientists to explore some of the most perplexing questions in physics and cosmology. Speakers include Freeman Dyson, Anton Zeilinger, Nicolas Gisin, J. Richard Gott, Daniel Greenberger, Mary Rowe, Lucien Hardy, Juan Maldacena, Wojciech Zurek, Bryce DeWitt, Max Tegmark, Raymond Chiao, Christopher Monroe, Nideo Mabuchi, Aephraim Steinberg, Jaroslav Pelikan, Philip Clayton, Kitty Ferguson, Timothy Ferris, Charles Harper, Andreas Albrecht, Andrei Linde, Joao Magueiro, Lisa Randall, Lee Smolin, Robert Laughlin, George Ellis, Marcelo Gleiser, and Stuart Kauffman. Topics include a tribute to Wheeler, theory and experiment of quantum reality, and cosmology.