Interview with Peter Galison, Joseph Pellegrino University Professor at Harvard. Galison describes his numerous and overlapping appointments across Harvard, which allow him to teach in both Physics and History of Science, as well as the Philosophy and Art, Film, and Visual Studies Departments. He recounts his upbringing in Manhattan and a formative year he spent in Paris doing plasma physics before enrolling at Harvard as an undergraduate. Galison talks about the impact of the course Math 55 and why early on he knew he wanted to pursue a course of study that combined science with the arts, which ultimately coalesced into a course of study on history of science with a focus on physics. He describes the intellectual influence of Clifford Geertz and his anti-Vietnam war activism at Harvard, and he conveys the excitement surrounding fundamental discoveries in particle physics in the late 1960s and early 1970s. Galison discusses his postgraduate year at Cambridge where he worked on the philosophy of relativistic quantum mechanics, and he explains his decision to return to Harvard for his thesis work. He discusses his entrance into the Harvard Society of Fellows with the support of Steve Weinberg and Ed Purcell, and he explains how his interests in the unified field theories of Weinberg-Salam-Glashow informed his dissertation work in physics and history of science. Galison traces the origins of his interest in the duality of Big Science and Small Science and the considerations he faced in choosing between physics and history of science for his postdoctoral work. He explains his decision to focus on the latter at Stanford where he joined what would come to be known as the Stanford School and how these collaborations informed his book How Experiments End. Galison describes his interest in experimentation as labor history and he discusses his connection to the physics department and to SLAC during his time at Stanford. He discusses the philosophical connotations around the idea that the concept of a multiverse is not science because it is not testable, and he mounts a defense of the future utility of string theory by drawing a distinction between what it demonstrates now against what it will demonstrate with further advance. Galison discusses his contributions to the Black Hole Initiative and the Event Horizon Telescope collaboration, and he surveys the current advances made possible by AI and machine learning. He traces his interest in using film as a medium for scholarly research for its ability to convey a density in human interaction that is not achievable in print, and he explains why the notion of government secrecy bridges his interest in physics and social systems. Galison reflects on his own decisions as a graduate student and the lessons he has tried to pass on to his students. At the end of the interview, Galison surveys his current interests, and connects his scholarship as an avenue to understanding the contemporary pandemic, the related challenge of the disconnect of scientific expertise and public policy, and why ultimately science will offer a path out of the crisis.