In this interview, George Miller, Director Emeritus at Lawrence Livermore National Laboratory, discusses his life and career. Miller recounts his early childhood in Mississippi, and his formative years in Virginia, where his family moved when his father joined the CIA. He discusses his education at the College of William and Mary, and his realization that he wanted to specialize in experimentation as a graduate student. Miller discusses his research under the direction of Bob Welsh, studying gamma rays from meson capture in materials. He discusses his postdoctoral work at Livermore, and the relevance of his graduate training on the weapons research and design programs at the lab. Miller explains the policy and technical processes that govern weapons research at Livermore, and the culture of risk-taking and its value toward meeting the lab's core objectives. Miller describes the promotions that led to his directorship at Livermore, and his increasing involvement with Washington and national security policy as he moved up the leadership chain. Miller describes the impact of the Strategic Defense Initiative (SDI) program on the lab, the Stockpile Stewardship program, and how Livermore responded to the changing security and budgetary environment following the end of the Cold War. He explains the key challenges Livermore faced under his leadership and what he sees as his key achievements, including his push to involve the lab in more civilian-oriented research.